Recently I come across with an annoying issue on Experience Editor on Sitecore 8.1. The “Save” Button suddenly stops working
First symptom: Save button becomes disabled(gray)
After debugging on Chrome developer Tools, I found this error
“Uncaught URIError: URI malformed”
Check your Sitecore version, if you are running Sitecore 8.1 Update 1 this may be your issue as well
After getting in touch with Sitecore they send me a fix on ExperienceEditor.js that must be replaced on the following path “sitecore\shell\client\Sitecore\ExperienceEditor\ExperienceEditor.js”
Download the File and Good Luck
Sitecore Tips 